Abstract
Term premature rupture of membranes (TPROM) is associated with an increased risk of infection of the mother and newborn. The current treatment of TPROM does not include prophylactic antibiotics, because systematic reviews conclude that its use does not modify maternal or neonatal outcomes. However, in the group of patients with latency at delivery greater than 12 hours, the rates of maternal infection, like chorioamnionitis and endometritis, are significantly lower with the use of antibiotics. One of the studies with latency greater than 12 hours concludes that the determinant risk factor of maternal infection is the presence of cervicovaginal infection (CVI) and / or microbial invasion of the amniotic cavity (MIAC), and not other traditional risk factors. This study reports that MIAC and maternal infection occur only in patients with CVI and that the significant reduction in maternal infection is probably due to the effect of antibiotics on CVI and on amniotic fluid infections. In agreement the known association between chorioamnionitis and perinatal infection/ cerebral palsy in the preterm rupture of membranes (PROM) of pregnancies less than < 34 weeks, it could be possible to affirm a reduction of the perinatal infection and the long-term neurological sequelae with the use of antibiotics in the TPROM. Additional studies are needed to clarify the benefit of antibiotics in patients with TPROM without labor and latency at delivery > 12 h.
For more info about article: http://www.sciaeon.org/articles/Is-The-Use-of-Antibiotics-Useful-in-Patients-with-Term-Premature-Rupture-of-Membranes.pdf
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Women's Health and Complications 