Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period. However, epidemiologic studies have revealed that 1% to 2% of women experience recurrent pregnancy loss. Recurrent early miscarriages (within the first trimester) are most commonly due to genetic or chromosomal problems of the embryo, with 50-80% of spontaneous losses having abnormal chromosomal number. Structural problems of the uterus can also play a role in early miscarriage. Approximately two out of every 10 pregnancies may result in a miscarriage. Women are considered to have recurrent pregnancy loss when they have two or three miscarriages in a row. Only about 1 percent of women will have three consecutive miscarriages or more
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