While some perinatal complications are more common in fetuses conceived using ART, difficulties arise in many studies with defining the risk of complications that is attributable to the process of ART itself. There are a number of important confounding factors that may well contribute to adverse outcomes including the high incidence of multiple pregnancies, the reasons for the underlying subfertility, poor gamete quality, and advanced maternal age. Fetal complications that are more common in pregnancies conceived using ART arise via a number of distinct mechanisms. There are those derived from the conceptus itself, which include chromosomal, genetic and imprinted disorders that can impact on fetal development.
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